Adenosine receptor antagonism suppresses functional and histological inflammatory changes in the rat urinary bladder

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10133991" target="_blank" >RIV/00216208:11160/12:10133991 - isvavai.cz</a>

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S1566070212001749" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1566070212001749</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.autneu.2012.10.006" target="_blank" >10.1016/j.autneu.2012.10.006</a>

Result language

angličtina

Original language name

Adenosine receptor antagonism suppresses functional and histological inflammatory changes in the rat urinary bladder

Original language description

Cyclophosphamide (CYP) induces an interstitial cystitis-like inflammation. The resulting bladder dysfunction has been associated with increased release of adenosine-5'-triphosphate (ATP), structural bladder wall changes and contractile impairment. Due tothe inflammatory modulatory effects of purines it was presently wondered if pre-treatment with P1 and P2 purinoceptor antagonists affect the CYP-induced alterations. Rats were pre-treated with saline or antagonists for five days, and 60 h before the invitro functional examination the rats were administered either saline or CYP. Histological examination revealed CYP-induced bladder wall thickening largely depending on submucosal enlargement, mast cell invasion of the detrusor muscle, increase in muscarinic M5 receptor expression and macrophage migration inhibitory factor (MIF) occurrence in large parts of the urothelium. Functionally, methacholine- and ATP-evoked contractions were smaller in urinary bladders from CYP-treated rats. Pre-

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Autonomic Neuroscience: Basic and Clinical

ISSN

1566-0702

e-ISSN

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Volume of the periodical

171

Issue of the periodical within the volume

1-2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

49-57

UT code for WoS article

000312417100009

EID of the result in the Scopus database

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