Separation and determination of chlorophenylpiperazine isomers in confiscated pills by capillary electrophoresis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F13%3A10145755" target="_blank" >RIV/00216208:11160/13:10145755 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0731708513002434" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0731708513002434</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jpba.2013.05.042" target="_blank" >10.1016/j.jpba.2013.05.042</a>

Result language
angličtina
Original language name
Separation and determination of chlorophenylpiperazine isomers in confiscated pills by capillary electrophoresis
Original language description
A simple capillary electrophoretic method with spectrophotometric UV detection at 236 nm has been developed for the selective separation and determination of 1-(2-chlorophenyl)piperazine (oCPP), 1-(3-chlorophenyl)piperazine (mCPP) and 1-(4-chlorophenyl)piperazine (pCPP) in confiscated pills. Several cyclodextrin derivatives were tested to compose the background electrolyte (BGE). The optimized BGE contained 20 mmol/L phosphoric acid adjusted to pH 2.5 with triethylamine and 10 mmol/L alpha-cyclodextrin,which provided acceptable resolution of analytes and candidate interferents in less. than 15 min. The analyses were performed at constant voltage of 25 kV in 60 cm (effective length 50 cm; 50 mu m i.d.) uncoated fused-silica capillary maintained at 25 Cwith sample injection at 4826 Pa for 8s. Procaine at a concentration of 0.1 mg/mL was used as internal standard (IS). Possible interference from other drugs such as amphetamine, methamphetamine, 3,4-methylenedioxyaniphetamine, 3,4-methyl
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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