Mass Spectrometric and Contactless Conductivity Detection Approaches in the Determination of Muscle Relaxants by Capillary Electrophoresis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F13%3A10145768" target="_blank" >RIV/00216208:11160/13:10145768 - isvavai.cz</a>

Result on the web

<a href="http://www.tandfonline.com/doi/full/10.1080/00032719.2013.798798" target="_blank" >http://www.tandfonline.com/doi/full/10.1080/00032719.2013.798798</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00032719.2013.798798" target="_blank" >10.1080/00032719.2013.798798</a>

Result language

angličtina

Original language name

Mass Spectrometric and Contactless Conductivity Detection Approaches in the Determination of Muscle Relaxants by Capillary Electrophoresis

Original language description

Novel and rapid capillary electrophoresis-coupled tandem mass spectrometry (CE-MS/MS) and capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C(4)D) methods have been developed for the separation and determination of three neuromuscular blocking agents: pancuronium, vecuronium, and rocuronium. In both cases, the separation was conducted in background electrolytes based on acidic acetate-ammonium buffers to avoid possible decomposition of the analytes that are knownto be unstable in alkaline media. Baseline resolution of the analytes was achieved in the presence of modified gamma-cyclodextrin by CE with C(4)D detection. The two detection techniques were compared with regard to analytical figures of merit includinglinear dynamic range, limit of detection, limit of quantification, precision, and accuracy. The calibration curves showed good linearity for both detection methods examined (characterized by r(2) }= 0.9908). The LODs of the CE-MS/MS and

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/EE2.3.30.0061" target="_blank" >EE2.3.30.0061: Increasing of the R&D capacity at Charles University through new positions for graduates of doctoral studies</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Analytical Letters

ISSN

0003-2719

e-ISSN

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Volume of the periodical

46

Issue of the periodical within the volume

14

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

2165-2179

UT code for WoS article

000323997100003

EID of the result in the Scopus database

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