Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F13%3A10145940" target="_blank" >RIV/00216208:11160/13:10145940 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1357272513002069" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1357272513002069</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biocel.2013.06.022" target="_blank" >10.1016/j.biocel.2013.06.022</a>
Alternative languages
Result language
angličtina
Original language name
Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics
Original language description
Mammal multidrug and toxin extrusion protein 1 (MATE 1) encoded by SLC47A1 gene was described in 2005 as an efflux transporter that mediates proton-coupled organic cation secretion. In the kidney and liver, MATEs work in concert with organic cation transporters (OCTs), together representing an eliminatory pathway for organic cations. Over 40 clinically used drugs and several endogenous compounds are known substrates or inhibitors of MATEs. These transporters are supposed to modulate pharmacokinetics/toxicokinetics and to play a role in drug resistance and (patho)physiological processes. Drug drug interactions on MATE transporters and polymorphisms in SLC47A genes may affect renal excretion of substrate drugs. Expression and function of MATEs in tissuesother than kidney and liver remain to be elucidated.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP303%2F12%2F0850" target="_blank" >GAP303/12/0850: Transplacental pharmacokinetics of antiretroviral drugs; interactions with drug-efflux transporters</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Biochemistry and Cell Biology
ISSN
1357-2725
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
2007-2011
UT code for WoS article
000324605300006
EID of the result in the Scopus database
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