Francisella tularensis subsp holarctica DsbA homologue: a thioredoxin-like protein with chaperone function
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F13%3A10210411" target="_blank" >RIV/00216208:11160/13:10210411 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/13:43874878
Result on the web
<a href="http://mic.sgmjournals.org/content/159/Pt_11/2364.full" target="_blank" >http://mic.sgmjournals.org/content/159/Pt_11/2364.full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1099/mic.0.070516-0" target="_blank" >10.1099/mic.0.070516-0</a>
Alternative languages
Result language
angličtina
Original language name
Francisella tularensis subsp holarctica DsbA homologue: a thioredoxin-like protein with chaperone function
Original language description
Francisella tularensis is a highly infectious facultative intracellular bacterium and aetiological agent of tularaemia. The conserved hypothetical lipoprotein with homology to thiol/disulphide oxidoreductase proteins (FtDsbA) is an essential virulence factor in F. tularensis. Its protein sequence has two different domains: the DsbA_Com1_like domain (DSBA), with the highly conserved catalytically active site CXXC and cis-proline residue; and the domain amino-terminal to FKBP-type peptidyl-prolyl isomerases (FKBP_N). To establish the role of both domains in tularaemia infection models, site-directed and deletion mutagenesis affecting the active site (AXXA), the cis-proline (P286T) and the FKBP_N domain (Delta FKBP_N) were performed. The generated mutations led to high attenuation with the ability to induce full or partial host protective immunity. Recombinant protein analysis revealed that the active site CXXC as well as the cis-proline residue and the FKBP_N domain are necessary for cor
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Microbiology
ISSN
1350-0872
e-ISSN
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Volume of the periodical
159
Issue of the periodical within the volume
November
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
2364-2374
UT code for WoS article
000328517600015
EID of the result in the Scopus database
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