The Chemistry and Biology of 6-Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10281636" target="_blank" >RIV/00216208:11160/14:10281636 - isvavai.cz</a>

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1002/cbic.201402153/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/cbic.201402153/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cbic.201402153" target="_blank" >10.1002/cbic.201402153</a>

Result language

angličtina

Original language name

The Chemistry and Biology of 6-Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family

Original language description

Sphingolipids are crucial for the life of the cell. In land-dwelling mammals, they are equally important outside the cell-in the extracellular space of the skin barrier-because they prevent loss of water. Although a large body of research has elucidatedmany of the functions of sphingolipids, their extensive structural diversity remains intriguing. A new class of sphingolipids based on 6-hydroxylated sphingosine has recently been identified in human skin. Abnormal levels of these 6-hydroxylated ceramides have repeatedly been observed in atopic dermatitis; however, neither the biosynthesis nor the roles of these unique ceramide subclasses have been established in the human body. In this Minireview, we summarize the current knowledge of 6-hydroxyceramides, including their discovery, structure, stereochemistry, occurrence in healthy and diseased human epidermis, and synthetic approaches to 6-hydroxysphingosine and related ceramides.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/GA13-23891S" target="_blank" >GA13-23891S: Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ChemBioChem

ISSN

1439-4227

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

11

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

1555-1562

UT code for WoS article

000339502900002

EID of the result in the Scopus database

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