Synthesis of 6-hydroxyceramide using ruthenium-catalyzed hydrosilylation-protodesilylation. Unexpected formation of a long periodicity lamellar phase in skin lipid membranes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F16%3A10326673" target="_blank" >RIV/00216208:11160/16:10326673 - isvavai.cz</a>
Result on the web
<a href="http://pubs.rsc.org/en/content/articlehtml/2016/ra/c6ra16565f" target="_blank" >http://pubs.rsc.org/en/content/articlehtml/2016/ra/c6ra16565f</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c6ra16565f" target="_blank" >10.1039/c6ra16565f</a>

Result language
angličtina
Original language name
Synthesis of 6-hydroxyceramide using ruthenium-catalyzed hydrosilylation-protodesilylation. Unexpected formation of a long periodicity lamellar phase in skin lipid membranes
Original language description
The synthesis of a ceramide with a 6-hydroxysphingosine base, a unique component of the human epidermal barrier, is reported. X-Ray powder diffraction on the model skin lipid membranes showed that 6-hydroxyceramide promotes the formation of a lamellar phase with 10.6 nm periodicity, which might explain why keratinocytes hydroxylate some ceramides at carbon 6.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/GA13-23891S" target="_blank" >GA13-23891S: Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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