Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10281766" target="_blank" >RIV/00216208:11160/14:10281766 - isvavai.cz</a>

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0968089614004234" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0968089614004234</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bmc.2014.05.064" target="_blank" >10.1016/j.bmc.2014.05.064</a>

Result language

angličtina

Original language name

Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates

Original language description

The development of novel antimicrobial drugs represents a cutting edge research topic. In this study, 20 salicylanilide N,N-disubstituted carbamates and thiocarbamates were designed, synthesised and characterised by IR, H-1 NMR and C-13 NMR. The compounds were evaluated in vitro as potential antimicrobial agents against Mycobacterium tuberculosis and nontuberculous mycobacteria (Mycobacterium avium and Mycobacterium kansasii) as well as against eight bacterial and fungal strains. Additionally, we investigated the inhibitory effect of these compounds on mycobacterial isocitrate lyase and cellular toxicity. The minimum inhibitory concentrations (MICs) against mycobacteria were from 4 mu M for thiocarbamates and from 16 mu M for carbamates. Gram-positivebacteria, including methicillin-resistant Staphylococcus aureus, were inhibited with MICs from 0.49 mu M by thiocarbamates, whilst Gram-negative bacteria and most of the fungi did not display any significant susceptibility. All (thio)carb

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioorganic and Medicinal Chemistry

ISSN

0968-0896

e-ISSN

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Volume of the periodical

22

Issue of the periodical within the volume

15

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

4073-4082

UT code for WoS article

000339859700032

EID of the result in the Scopus database

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