Revised NMR Data for 9-O-Demethylgalanthine: an Alkaloid from Zephyranthes robusta (Amaryllidaceae) and its Biological Activity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10281882" target="_blank" >RIV/00216208:11160/14:10281882 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/14:43875118

Result on the web

<a href="http://pubget.com/paper/25115079" target="_blank" >http://pubget.com/paper/25115079</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Revised NMR Data for 9-O-Demethylgalanthine: an Alkaloid from Zephyranthes robusta (Amaryllidaceae) and its Biological Activity

Original language description

Ongoing studies of Zephyranthes robusta resulted in the isolation of the lycorine-type alkaloid previously called carinatine and 10-O-demethylgalanthine. The NMR data given previously for this compound were revised and completed by two-dimensional H-1-H-1 and H-1-C-13 chemical shift correlation experiments. The name of the isolated compound was corrected to 9-O-demethylgalanthine in accordance with the currently used system of numbering of lycorine-type alkaloids. 9-O-Demethylgalanthine and galanthine,a previously isolated alkaloid from Z. robusta, were inactive in acetylcholinesterase/butyrylcholinesterase assays (IC50> 500 mu M), but showed important prolyl oligopeptidase inhibition activity.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

<a href="/en/project/GAP303%2F11%2F1907" target="_blank" >GAP303/11/1907: Novel inhibitors of acetylcholinesterase derived from 7-MEOTA - potential Alzheimer´s disease drugs</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Natural product communications

ISSN

1934-578X

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

2

Pages from-to

787-788

UT code for WoS article

000338095300014

EID of the result in the Scopus database

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