Alkaloids from Zephyranthes robusta Baker and Their Acetylcholinesterase- and Butyrylcholinesterase-Inhibitory Activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F13%3A10144282" target="_blank" >RIV/00216208:11160/13:10144282 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/cbdv.201200144/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/cbdv.201200144/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cbdv.201200144" target="_blank" >10.1002/cbdv.201200144</a>

Result language
angličtina
Original language name
Alkaloids from Zephyranthes robusta Baker and Their Acetylcholinesterase- and Butyrylcholinesterase-Inhibitory Activity
Original language description
The bulbs of Zephyranthes robusta (Amaryllidaceae) have been extensively analyzed for their chemical constituents, resulting in the isolation of 13 alkaloids. The chemical structures of the isolated compounds were elucidated by mass-spectrometric, and 1D- and 2D-NMR spectroscopic experiments. The complete NMR assignments were achieved for hippeastidine. All isolated alkaloids were evaluated for their erythrocytic acetylcholinesterase and serum butyrylcholinesterase inhibitory activities using the Ellman's method. Significant acetylcholinesterase inhibition activity was exhibited by 8-O-demethylmaritidine (IC50(HuAChE) 28.0 +/- 0.9M).
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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