5-Bromo- and 3,5-dibromo-2-hydroxy-N-phenylbenzamides - inhibitors of photosynthesis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10293795" target="_blank" >RIV/00216208:11160/14:10293795 - isvavai.cz</a>

Result on the web

<a href="http://www.degruyter.com/view/j/chempap.2014.68.issue-1/s11696-013-0416-7/s11696-013-0416-7.xml" target="_blank" >http://www.degruyter.com/view/j/chempap.2014.68.issue-1/s11696-013-0416-7/s11696-013-0416-7.xml</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/s11696-013-0416-7" target="_blank" >10.2478/s11696-013-0416-7</a>

Result language

angličtina

Original language name

5-Bromo- and 3,5-dibromo-2-hydroxy-N-phenylbenzamides - inhibitors of photosynthesis

Original language description

5-Bromo-(Br-PBA) and 3,5-dibromo-2-hydroxy-N-phenylbenzamides (Br-2-PBA) inhibited photosynthetic electron transport (PET) and their inhibitory efficiency depended on the compound lipophilicity as well as on the electronic properties of the R substituentin the N-phenyl moiety. Br-PBA showed higher PET inhibiting activity than Br-2-PBA with the same R substituent. The most effective inhibitors in the tested series were the derivatives with R = 3-F (Br-PBA; IC50 = 4.3 mu mol dm(-3)) and R = 3-Cl (Br-2-PBA; IC50 = 8.6 mu mol dm(-3)). Bilinear dependence of the PET inhibiting activity on the lipophilicity of the compounds as well as on the Hammett constant, sigma, of the R substituent was observed for both investigated series. Using EPR spectroscopy it was found that the site of action of the tested compounds in the photosynthetic apparatus is situated on the donor side of PS 2, in D. or in the Z./D. intermediates. Interaction of the studied compounds with chlorophyll a and aromatic amino

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemical Papers

ISSN

0366-6352

e-ISSN

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Volume of the periodical

68

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

7

Pages from-to

46-52

UT code for WoS article

000324491200006

EID of the result in the Scopus database

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