Structure-Activity Relationships of N-benzylsalicylamides for Inhibition of Photosynthetic Electron Transport

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10317027" target="_blank" >RIV/00216208:11160/15:10317027 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/15:43873828

Result on the web

<a href="http://benthamscience.com/journals/medicinal-chemistry/volume/11/issue/2/page/156/" target="_blank" >http://benthamscience.com/journals/medicinal-chemistry/volume/11/issue/2/page/156/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1573406410666140815125004" target="_blank" >10.2174/1573406410666140815125004</a>

Result language

angličtina

Original language name

Structure-Activity Relationships of N-benzylsalicylamides for Inhibition of Photosynthetic Electron Transport

Original language description

Inhibition of photosynthetic electron transport (PET) in spinach chloroplasts by sixty-one ring-substituted N-benzylsalicylamides was investigated. The inhibitory potency of the compounds expressed by IC50 value varied from 2.0 to 425.3 mu mol/L. Severalevaluated compounds can be considered as effective PET inhibitors; these include N-(3,4-dichlorobenzyl)-2-hydroxy-5-nitrobenzamide (IC50 = 2.0 mu mol/L), 3,5-dibromo-N-(3,4-dichlorobenzyl)-2-hydroxybenzamide (IC50 = 2.3 mu mol/L) and 3,5-dibromo-N-(4-chlorobenzyl)-2-hydroxybenzamide (IC50 = 2.6 mu mol/L) with activity comparable with that of the standard Diuron (IC50 = 1.9 mu mol/L). The PET inhibiting activity increased approximately linearly with increasing lipophilicity of the compounds as well as with the increasing sum of Hammett sigma constants of the substituents on the acyl fragment (R-1 = H, 5-OCH3, 5-CH3, 5-Cl, 5-Br, 5-NO2, 4-OCH3, 4-Cl, 3,5-Cl and 3,5-Br) and the benzylamide fragment (R-2 = H, 4-OCH3, 4-CH3, 4-F, 4-Cl and 3,

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medicinal Chemistry

ISSN

1573-4064

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

2

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

9

Pages from-to

156-164

UT code for WoS article

000349331700007

EID of the result in the Scopus database

2-s2.0-84926490456