Development of a Gradient HPLC Method for the Simultaneous Determination of Sotalol and Sorbate in Oral Liquid Preparations Using Solid Core Stationary Phase

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10294607" target="_blank" >RIV/00216208:11160/15:10294607 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/15:10294607

Result on the web

<a href="http://www.hindawi.com/journals/jamc/2015/806736/" target="_blank" >http://www.hindawi.com/journals/jamc/2015/806736/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2015/806736" target="_blank" >10.1155/2015/806736</a>

Result language

angličtina

Original language name

Development of a Gradient HPLC Method for the Simultaneous Determination of Sotalol and Sorbate in Oral Liquid Preparations Using Solid Core Stationary Phase

Original language description

A selective and sensitive gradient HPLC-UV method for quantification of sotalol hydrochloride and potassium sorbate in five types of oral liquid preparations was developed and fully validated. The separation of an active substance sotalol hydrochloride,potassium sorbate (antimicrobial agent), and other substances (for taste and smell correction, etc.) was performed using an Ascentis Express C18 (100 x 4.6 mm, particles 2.7 mu m) solid core HPLC column. Linear gradient elution mode with a flow rate of 1.3 mL min(-1) was used, and the injection volume was 5 mu L. The UV/Vis absorbance detector was set to a wavelength of 237 nm, and the column oven was conditioned at 25 degrees C. A sodium dihydrogen phosphate dihydrate solution (pH 2.5; 17.7 mM) was used as the mobile phase buffer. The total analysis time was 4.5 min (+ 2.5 min for reequilibration). The method was successfully employed in a stability evaluation of the developed formulations, which are now already being used in the thera

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/EE2.3.20.0235" target="_blank" >EE2.3.20.0235: Establishment of Research Team Focused on Experimental and Applied Biopharmacy</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Analytical Methods in Chemistry

ISSN

2090-8865

e-ISSN

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Volume of the periodical

2015

Issue of the periodical within the volume

March

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

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UT code for WoS article

000352380300001

EID of the result in the Scopus database

2-s2.0-84926637040