Antifungal and Antibacterial Activity of Extracts and Alkaloids of Selected Amaryllidaceae Species
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312362" target="_blank" >RIV/00216208:11160/15:10312362 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41210/15:68008 RIV/60460709:41340/15:68008
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Antifungal and Antibacterial Activity of Extracts and Alkaloids of Selected Amaryllidaceae Species
Original language description
Alkaloidal extracts of six selected species of Amaryllidaceae were studied with respect to their antibacterial and anti-yeast activity and their alkaloidal fingerprint. Twenty-five alkaloids were determined by GC/MS, and sixteen of them identified from their mass spectra, retention times and retention indexes. In the antimicrobial assay, Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus were used, along with isolates of the human pathogenic yeasts Candida albicans, C. glabrata, C. dubliniensis and Lodderomyces elongiosporus. The six extracts, together with 19 Amaryllidaceae alkaloids isolated in our laboratory, showed almost no inhibitory activity against the bacteria tested. However, promising anti-yeast properties were detected;the most potent activity was shown by lycorine, which inhibited C. dubliniensis with a MIC of 32 mu g/mL, C. albicans and L. elongiosporus, both with MICs of 64 mu g/mL, followed by caranine inhibiting C. dubliniensis with a MIC of 128 mu
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Natural Product Communications
ISSN
1934-578X
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
1537-1540
UT code for WoS article
000361868900012
EID of the result in the Scopus database
2-s2.0-84954596731