Atorvastatin-induced endothelial nitric oxide synthase expression in endothelial cells is mediated by endoglin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312714" target="_blank" >RIV/00216208:11160/15:10312714 - isvavai.cz</a>

Result on the web

<a href="http://www.jpp.krakow.pl/journal/archive/06_15/pdf/403_06_15_article.pdf" target="_blank" >http://www.jpp.krakow.pl/journal/archive/06_15/pdf/403_06_15_article.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Atorvastatin-induced endothelial nitric oxide synthase expression in endothelial cells is mediated by endoglin

Original language description

Endoglin, a transforming growth factor beta (TGF-beta) receptor type III, is co-expressed with endothelial nitric oxide synthase (eNOS) in aortic endothelium in atherosclerotic plaques of mice. Interestingly, atorvastatin (ATV) is able to increase both endoglin and eNOS expression and reduce plaque size beyond its lipid lowering effects but by unknown mechanisms. We hypothesized whether inflammation modulates ATV-dependent induction of endoglin and eNOS expression in vitro in endothelial cells and whether ATV-induced eNOS expression is regulated via endoglin. After treatment of human umbilical vein endothelial cells (HUVECs) with TNF-alpha, endoglin and eNOS protein expression was reduced, concomitantly with increased levels of cell surface VCAM-1 andsoluble endoglin, as determined by flow cytometry, Western blot and ELISA analyses. By contrast, ATV treatment increased endoglin and eNOS protein expression, while preventing TNF-alpha-mediated downregulation of endoglin and eNOS protein

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

<a href="/en/project/EE2.3.30.0061" target="_blank" >EE2.3.30.0061: Increasing of the R&D capacity at Charles University through new positions for graduates of doctoral studies</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Physiology and Pharmacology

ISSN

0867-5910

e-ISSN

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Volume of the periodical

66

Issue of the periodical within the volume

3

Country of publishing house

PL - POLAND

Number of pages

11

Pages from-to

403-413

UT code for WoS article

000357361400009

EID of the result in the Scopus database

2-s2.0-84930901347