The role of endoglin in atherosclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10124865" target="_blank" >RIV/00216208:11160/12:10124865 - isvavai.cz</a>

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S002191501200158X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S002191501200158X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.atherosclerosis.2012.03.001" target="_blank" >10.1016/j.atherosclerosis.2012.03.001</a>

Result language

angličtina

Original language name

The role of endoglin in atherosclerosis

Original language description

Endoglin (CD 105, TGF-beta receptor III) is a homodimeric transmembrane glycoprotein that plays a regulatory role in TGF-beta signaling. Its functional role in the context of atherosclerosis has yet to be defined and should be stated here. Therefore, wefocused on the role of endoglin in atherosclerosis in both humans and experimental animals. Endoglin expression was demonstrated in atherosclerotic vessels predominantly in endothelial cells and smooth muscle cells in various types of blood vessels in mice and humans, suggesting its participation in atherogenesis. Endoglin expression was also related to the expression of eNOS in endothelium, repair of the vessel wall, plaque neoangiogenesis, production of collagen and stabilization of atherosclerotic lesions. In addition, increased levels of soluble endoglin were associated with hypercholesterolemia, atherosclerosis, acute myocardial infarction and were related to inhibition of TGF-beta signaling in the vessel wall. Moreover, soluble en

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Atherosclerosis

ISSN

0021-9150

e-ISSN

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Volume of the periodical

224

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

4-11

UT code for WoS article

000308078000002

EID of the result in the Scopus database

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