The role of TGF-beta and TGF-beta receptors in atherosclerosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10124901" target="_blank" >RIV/00216208:11160/12:10124901 - isvavai.cz</a>
Result on the web
<a href="http://www.intechopen.com/books/atherogenesis/the-role-of-tgf-beta-and-tgf-beta-receptors-in-atherosclerosis" target="_blank" >http://www.intechopen.com/books/atherogenesis/the-role-of-tgf-beta-and-tgf-beta-receptors-in-atherosclerosis</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/26205" target="_blank" >10.5772/26205</a>

Result language
angličtina
Original language name
The role of TGF-beta and TGF-beta receptors in atherosclerosis
Original language description
The data presented in this chapter show the importance of TGF-beta1 signaling in atherosclerosis in both animals and humans. Despite a few papers showing participation of TGF-beta1 in early atherosclerosis, most of the papers demonstrate atheroprotectiveeffects of TGF-beta1 signaling. Activation of TGF-beta1 signaling pathway results in anti-inflammatory effects, including decreased expression of cell adhesion molecules (with participation of Smad2 and endoglin), inhibition of inflammation in macrophages, T-cells (with participation of Smad3), increased expression of nitric oxide synthase (with participation of endoglin and Smad2), smooth muscle cells production of collagen and plaques stabilization (with participation of endoglin and Smad2/3). Moreover, reduction of cholesterol levels and/or statin treatment significantly enhances atheroprotective effects of TGF-beta1 signaling.
Czech name
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Czech description
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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