Cyclin A down-regulation in TGF beta 1-arrested follicular lymphoma cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F00%3A00003750" target="_blank" >RIV/00216208:11120/00:00003750 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1006/excr.2000.5047" target="_blank" >http://dx.doi.org/10.1006/excr.2000.5047</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1006/excr.2000.5047" target="_blank" >10.1006/excr.2000.5047</a>
Alternative languages
Result language
angličtina
Original language name
Cyclin A down-regulation in TGF beta 1-arrested follicular lymphoma cells
Original language description
Transforming growth factor beta1 (TGF beta1) induces growth arrest in many cell types, including B lymphocytes. We examined the effect of TGF on cell cycle progression of a non-Hodgkin lymphoma cell line of follicular lymphoma subtype (FL). After 48 h ofTGF beta1 (10 ng/ml) treatment, a significantly increased number of DoHH2 cells was retained in G(0)/G(1) phase. We examined the level of cell cycle components, cyclins, cyclin-dependent kinases (cdk), and their inhibitors. We found that the expressionof cyclin A and p21(WAF1) molecules was primarily modulated by TGF beta1 treatment while the expression of other regulatory components, like cyclins D, cyclin E, cdk2, cdk4, and cdk6 or p15(INK4B), p16(INK4A), and p27(KIP1) was not significantly affected. We further examined expression and activity of CREB/ATF family members to examine their roles in cyclin A inhibition. The binding activity of CREB-1 and ATF-8 to the CRE region of the cyclin A promoter was almost completely abolished du
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/VS96129" target="_blank" >VS96129: Laboratory of gene expression</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2000
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental Cell Research
ISSN
0014-4827
e-ISSN
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Volume of the periodical
261
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
250-259
UT code for WoS article
000165622200027
EID of the result in the Scopus database
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