Soman and VX: different effect on cellular signalling

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874692" target="_blank" >RIV/60162694:G44__/12:43874692 - isvavai.cz</a>
Result on the web
<a href="http://www.zsf.jcu.cz/jab" target="_blank" >http://www.zsf.jcu.cz/jab</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/v10136-011-0018-z" target="_blank" >10.2478/v10136-011-0018-z</a>

Result language
angličtina
Original language name
Soman and VX: different effect on cellular signalling
Original language description
The purpose of our study was to examine the early expression of p21 and activated transcription factors ATF-2, CREB, Elk-1, p53 after soman and VX poisoning, to throw light on the pathogenetic mechanism of nerve agent-induced non-specific effects. Male Wistar rats were i.m. poisoned by soman (60 mu g.kg(-1) - 70% LD50) or VX (8 mu g.kg(-1) - 70% LD50). Samples were taken 4, 24, and 72 hours after poisoning, immunohistochemically stained and phospho-ATF-2(Thr-69/71), phospho-CREBSer-133, phospho-Elk-1(Ser-383), phospho-p53(Ser-15), and protein p21 expressions were measured using computer Image analysis in apical and cryptal enterocytes of the colon transversum. After soman poisoning, we observed an increased phospho-CREB in cryptal enterocytes 4, 24, and 72 h after poisoning, while apical enterocytes expressed increased phospho-CREB only 72 h after intoxication. Phospho-Elk-1 significantly dropped 4 and 24 h after soman poisoning in the cryptal compartment. Activation of ATF-2 and p53 a
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/OVUOFVZ200812" target="_blank" >OVUOFVZ200812: Short-term and long-term nonspecific changes in organisms exposed to high and low doses of nerve agents on cellular and molecular level</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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