Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00047019" target="_blank" >RIV/00216224:14110/10:00047019 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome

Original language description

Though pathophysiology of PHH is more complicated and TGF-beta1 is not the only one to play a role in it, we have documented in our study that TGF-beta1 level in CSF collected in the beginning of temporary treatment of PHH correlates with failure of CSFresorption. In our study, in 62.5% of patients with proof of obstruction, hyporesorptive component was present. Overall, ETV success rate in therapy of obstructive PHH 37.5% in our study. We have proven that premature newborns with lower TGF-beta1 leveland proof of obstructive HDC on MRI have significantly higer success rate of endoscopic treatment. In our study, ETV success rate was 100% in this group. Our results show that TGF-beta1 may influence succes rate of ETV in treatment of PHH, and based on its levels, it is possible to choose patients with purely obstructive hydrocephalus.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Childs Nerv Syst

ISSN

0256-7040

e-ISSN

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Volume of the periodical

26

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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