TGF-beta1 signaling plays a dominant role in the crosstalk between TGF-beta1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F12%3A00381596" target="_blank" >RIV/68081707:_____/12:00381596 - isvavai.cz</a>
Alternative codes found
RIV/00027162:_____/12:#0000943 RIV/00159816:_____/12:#0000961 RIV/00216224:14310/12:00081842
Result on the web
<a href="http://dx.doi.org/10.1016/j.cellsig.2012.04.008" target="_blank" >http://dx.doi.org/10.1016/j.cellsig.2012.04.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cellsig.2012.04.008" target="_blank" >10.1016/j.cellsig.2012.04.008</a>

Result language
angličtina
Original language name
TGF-beta1 signaling plays a dominant role in the crosstalk between TGF-beta1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells
Original language description
We demonstrated that TGF-beta1 suppresses the AhR-mediated gene expression through multiple mechanisms, involving inhibition of AhR expression and downregulation of nuclear AhR, via a SMAD4-dependent pathway. Our observations suggest that, in the contextof prostate epithelium, TGF-beta1 signaling plays a dominant role in the crosstalk with AhR signaling pathway.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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