Regulation of drug transporter expression and function in the placenta

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312745" target="_blank" >RIV/00216208:11160/15:10312745 - isvavai.cz</a>
Result on the web
<a href="http://www.tandfonline.com/doi/full/10.1517/17425255.2015.1005073" target="_blank" >http://www.tandfonline.com/doi/full/10.1517/17425255.2015.1005073</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1517/17425255.2015.1005073" target="_blank" >10.1517/17425255.2015.1005073</a>

Result language
angličtina
Original language name
Regulation of drug transporter expression and function in the placenta
Original language description
Introduction: Medication of pregnant women is increasingly common in developed countries. Several placental drug transporters have been shown to transfer their substrates from the trophoblast back to the maternal circulation, thus hindering the transplacental passage of xenobiotics and protecting the fetus. However, the expression and activity of drug transporter proteins in the placenta vary during gestation and are tightly regulated by many factors. In addition, their function can be compromised by pathological conditions and/or drug-drug interactions. Areas covered: This article reviews current knowledge on placental drug transporters, their effects on placental pharmacokinetics and the regulatory mechanisms that control their expression and activity. Transcriptional, genetic and epigenetic mechanisms of placental transporter regulation and the drug-drug interactions that modulate transporter activity are described. Physiological and pathological factors that can affect drug transpo
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/GAP303%2F12%2F0850" target="_blank" >GAP303/12/0850: Transplacental pharmacokinetics of antiretroviral drugs; interactions with drug-efflux transporters</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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