Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10282280" target="_blank" >RIV/00216208:11160/14:10282280 - isvavai.cz</a>
Result on the web
<a href="http://informahealthcare.com/doi/full/10.3109/03602532.2013.835819" target="_blank" >http://informahealthcare.com/doi/full/10.3109/03602532.2013.835819</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/03602532.2013.835819" target="_blank" >10.3109/03602532.2013.835819</a>

Result language
angličtina
Original language name
Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier
Original language description
Over the past 20 years, the toxicological and protective roles of the placental barrier with respect to drug detoxification and transporter-controlled protection of the fetus have been intensively examined. Several cytochrome P450 enzymes are expressed in placental trophoblast at different stages of pregnancy, though only a few of these have functional activity to metabolize xenobiotics. Drug transporters such as P-glycoprotein/MDR1 or breast cancer resistance protein (BCRP) are highly expressed in theplacenta, and their functional activities have been demonstrated in the placenta both in vitro and in vivo. In addition, several studies have reported on ligand-activated transcription factors and nuclear receptors referred to as "xenosensors'' in the placenta. The xenosensors control transcriptional regulation of both xenobiotic-metabolizing enzymes and drug transporters in different organs. Their ligands include toxic compounds and environmental pollutants, drugs, as well as herbal, di
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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