The Aryl Hydrocarbon Receptor in the Human Placental Trophoblast: The Impact of Nutraceuticals and Natural Products
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312787" target="_blank" >RIV/00216208:11160/15:10312787 - isvavai.cz</a>
Result on the web
<a href="http://www.crcnetbase.com/doi/10.1201/b19151-28" target="_blank" >http://www.crcnetbase.com/doi/10.1201/b19151-28</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1201/b19151-28" target="_blank" >10.1201/b19151-28</a>
Alternative languages
Result language
angličtina
Original language name
The Aryl Hydrocarbon Receptor in the Human Placental Trophoblast: The Impact of Nutraceuticals and Natural Products
Original language description
The aryl hydrocarbon receptor (AHR) and its heterodimer AHR nuclear translocator (ARNT) form a ligand-activated transcription complex that regulates the expression of numerous target genes involved in the biotransformation of both xenobiotic and endogenous compounds, including cytochrome P450 enzymes CYP1A1, CYP1A2, and CYP1B1; glutathione S-transferase GST1; UDP-glucuronosyltransferases UGT1A1 and UGT1A6; NAD(P)H-dependent quinone dehydrogenase NQO1; aldehyde dehydrogenase ALDH3A1; and breast cancer resistance protein. Placental expression, as well as the ontogeny of AHR, has been recently described both in human or rat placenta, and the regulation of its target genes has been studied in the placental trophoblast. Interestingly, of the AHR target genes, only cytochrome P450 CYP1A1 has been found to be significantly inducible in the human placental trophoblast, with significant enzymatic activities having been described. Herein, we summarize recent findings related to the toxicological
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centre of drug-dietary supplements interactions and nutrigenetics</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Human Placental Trophoblasts : Impact of Maternal Nutrition
ISBN
978-1-4822-5428-0
Number of pages of the result
16
Pages from-to
329-344
Number of pages of the book
426
Publisher name
CRC Press
Place of publication
Boca Raton
UT code for WoS chapter
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