Effects of glucocorticoids on cytochrome P450 1A1 (CYP1A1) expression in isolated human placental trophoblast

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33145267" target="_blank" >RIV/61989592:15310/13:33145267 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/13:10145998 RIV/61989592:15110/13:33145267

Result on the web

<a href="http://dx.doi.org/10.2478/v10136-012-0022-y" target="_blank" >http://dx.doi.org/10.2478/v10136-012-0022-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/v10136-012-0022-y" target="_blank" >10.2478/v10136-012-0022-y</a>

Result language

angličtina

Original language name

Effects of glucocorticoids on cytochrome P450 1A1 (CYP1A1) expression in isolated human placental trophoblast

Original language description

Antenatal glucocorticoid administration is used in cases of fetuses at risk to be born prematurely to enhance fetal pulmonary surfactant production and prevent infant respiratory distress syndrome. The CYP1A1 is the most important xenobiotic-metabolizingcytochrome P450 enzyme in the human placenta. Importantly, CYP1A1 generates reactive species and its placental activity is elevated in smoking women. CYP1A1 expression is mainly controlled by aryl hydrocarbon receptor (AHR) ligands. Glucocorticoid co-regulation of CYP1A1 has been described in various cell types but has not been systematically examined in the human placental trophoblast. We studied the effects of the glucocorticoids dexamethasone and betamethasone on inducibility of CYP1A1 and other AHRtarget genes CYP1A2, CYP1B1, UGT1A1 (UDP-glucuronosyltransferase 1A1) and BCRP (Breast cancer resistance protein) by prototype AHR ligand -methylcholanthrene (3MC) in isolated human placental trophoblast culture. We show that glucocortic

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

163-172

UT code for WoS article

000315854000005

EID of the result in the Scopus database

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