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The in vivo disposition and in vitro transmembrane transport of two model radiometabolites of DOTA-conjugated receptor-specific peptides labelled with Lu-177

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10314528" target="_blank" >RIV/00216208:11160/15:10314528 - isvavai.cz</a>

  • Result on the web

    <a href="http://onlinelibrary.wiley.com/doi/10.1002/jlcr.3352/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jlcr.3352/full</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/jlcr.3352" target="_blank" >10.1002/jlcr.3352</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The in vivo disposition and in vitro transmembrane transport of two model radiometabolites of DOTA-conjugated receptor-specific peptides labelled with Lu-177

  • Original language description

    In vivo metabolism of the radiolabelled receptor-specific peptides has been described; however, information regarding the pharmacokinetic behaviour of the degradation products within the body is very scarce. The present study was designed to obtain new knowledge on the isposition and elimination of low-molecular radiometabolites of receptor-specific peptides in the organism and to reveal the potential involvement of selected membrane transport mechanisms in the cellular uptake of radiometabolites, especially in the kidney. The study compared pharmacokinetics of two radiometabolites: a final metabolite of somatostatin analogues, 177Lu-DOTA-DPhe, and a tripeptide metabolite of 177Lu-DOTA-minigastrin 11, 177Lu-DOTA-DGlu-Ala-Tyr. Their pharmacokinetics wascompared with that of respective parent 177Lu-radiopeptide. Both radiometabolites exhibited relative rapid clearing from most body tissues in rats in vivo along with predominant renal excretion. The long-term renal retention of the small

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/EE2.3.30.0061" target="_blank" >EE2.3.30.0061: Increasing of the R&D capacity at Charles University through new positions for graduates of doctoral studies</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Labelled Compounds and Radiopharmaceuticals

  • ISSN

    0362-4803

  • e-ISSN

  • Volume of the periodical

    58

  • Issue of the periodical within the volume

    13-14

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    7

  • Pages from-to

    483-489

  • UT code for WoS article

    000366056300005

  • EID of the result in the Scopus database

    2-s2.0-84955211596