The in vivo disposition and in vitro transmembrane transport of two model radiometabolites of DOTA-conjugated receptor-specific peptides labelled with Lu-177
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10314528" target="_blank" >RIV/00216208:11160/15:10314528 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/jlcr.3352/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jlcr.3352/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jlcr.3352" target="_blank" >10.1002/jlcr.3352</a>
Alternative languages
Result language
angličtina
Original language name
The in vivo disposition and in vitro transmembrane transport of two model radiometabolites of DOTA-conjugated receptor-specific peptides labelled with Lu-177
Original language description
In vivo metabolism of the radiolabelled receptor-specific peptides has been described; however, information regarding the pharmacokinetic behaviour of the degradation products within the body is very scarce. The present study was designed to obtain new knowledge on the isposition and elimination of low-molecular radiometabolites of receptor-specific peptides in the organism and to reveal the potential involvement of selected membrane transport mechanisms in the cellular uptake of radiometabolites, especially in the kidney. The study compared pharmacokinetics of two radiometabolites: a final metabolite of somatostatin analogues, 177Lu-DOTA-DPhe, and a tripeptide metabolite of 177Lu-DOTA-minigastrin 11, 177Lu-DOTA-DGlu-Ala-Tyr. Their pharmacokinetics wascompared with that of respective parent 177Lu-radiopeptide. Both radiometabolites exhibited relative rapid clearing from most body tissues in rats in vivo along with predominant renal excretion. The long-term renal retention of the small
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/EE2.3.30.0061" target="_blank" >EE2.3.30.0061: Increasing of the R&D capacity at Charles University through new positions for graduates of doctoral studies</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Labelled Compounds and Radiopharmaceuticals
ISSN
0362-4803
e-ISSN
—
Volume of the periodical
58
Issue of the periodical within the volume
13-14
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
483-489
UT code for WoS article
000366056300005
EID of the result in the Scopus database
2-s2.0-84955211596