Stimulation of PPAR alpha normalizes the skin lipid ratio and improves the skin barrier of normal and filaggrin deficient reconstructed skin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10322892" target="_blank" >RIV/00216208:11160/15:10322892 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0923181115300529" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0923181115300529</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jdermsci.2015.09.012" target="_blank" >10.1016/j.jdermsci.2015.09.012</a>

Result language
angličtina
Original language name
Stimulation of PPAR alpha normalizes the skin lipid ratio and improves the skin barrier of normal and filaggrin deficient reconstructed skin
Original language description
Background: Therapeutic options for atopic dermatitis mostly address the symptoms but causal therapies are still missing. Peroxisome proliferator activated receptor (PPAR) agonists exert beneficial effects in patients suffering this disease, whereas thestimulation of PPAR alpha and gamma seemed most promising. Objectives: To elucidate the effects of the PPARa specific agonist WY14643, the PPAR gamma agonist ciglitazone, and the dual PPAR alpha + gamma agonist docosahexaenoic acid (DHA) on the homeostasis and barrier function of filaggrin deficient skin. Methods: The effects of the PPAR agonists on skin differentiation were evaluated via qPCR, Western blot, histological or immunofluorescence staining. Skin lipid organization was determined by ATR-FTIRand lipid composition was analyzed by HPTLC. Ultimately, the skin barrier function was assessed by skin absorption studies using the radioactively labeled compound testosterone. Results: Significant upregulation of filaggrin after DHA and
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/GA13-23891S" target="_blank" >GA13-23891S: Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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