Structure activity relationship of flavonoids as PPARγ agonists

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F25%3A00143900" target="_blank" >RIV/00216224:14160/25:00143900 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s11101-025-10121-w?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate" target="_blank" >https://link.springer.com/article/10.1007/s11101-025-10121-w?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11101-025-10121-w" target="_blank" >10.1007/s11101-025-10121-w</a>

Result language
angličtina
Original language name
Structure activity relationship of flavonoids as PPARγ agonists
Original language description
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a transcriptional factor and key regulatory element in glucose and lipid metabolism. We have attempted to determine the structure-activity relationship between flavonoids as PPAR gamma agonists through a literature search. To compare results from different studies and methods, we have recalculated them to the percentage of positive control (%PC). We have also described various methods used to determine PPAR gamma agonists. The most promising PPAR gamma agonists are isoflavones, namely 4'-fluoro-7-hydroxyisoflavone (4; %PC = 710.3%). The results presented in this review could be used for further semisynthetic modifications of flavonoids to enhance their PPAR gamma agonistic activity.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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