Lanthanide(III) complexes are more active inhibitors of the Fenton reaction than pure ligands
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F16%3A10312744" target="_blank" >RIV/00216208:11160/16:10312744 - isvavai.cz</a>
Result on the web
<a href="http://www.tandfonline.com/doi/full/10.1179/1351000215Y.0000000031" target="_blank" >http://www.tandfonline.com/doi/full/10.1179/1351000215Y.0000000031</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1179/1351000215Y.0000000031" target="_blank" >10.1179/1351000215Y.0000000031</a>
Alternative languages
Result language
angličtina
Original language name
Lanthanide(III) complexes are more active inhibitors of the Fenton reaction than pure ligands
Original language description
Objectives: This study is an extension to our finding of direct anti-oxidant activities of lanthanide(III) complexes with the heterocyclic compound, 5-aminoorotic acid (AOA). In this experiment, we used AOA and coumarin-3-carboxylic acid as the two heterocyclic compounds with anti-oxidant potential, to produce the complexes with different lanthanides. Methods: Lanthanide(III) complexes were tested on the iron-driven Fenton reaction. The product of this reaction, the hydroxyl radical, was detected by HPLC. Results: All complexes as well as their ligands had positive or neutral effect on the Fenton reaction but their behavior was different. Both pure ligands in low concentration ratio to iron were inefficient in contrast to some of their complexes. Complexes of neodymium, samarium, gadolinium, and partly of cerium blocked the Fenton reaction at very low ratios (in relation to iron) but the effect disappeared at higher ratios. In contrast, lanthanum complexes appeared to be the most promising. Both blocked the Fenton reaction in a dose-dependent manner. Conclusion: Lanthanide(III) complexes were proven to block the iron-driven production of the hydroxyl radical. Second, the lanthanide(III) element appears to be crucial for the anti-oxidant effect. Overall, lanthanum complexes may be promising direct anti-oxidants for future testing.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centre of drug-dietary supplements interactions and nutrigenetics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Redox Report
ISSN
1351-0002
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
2
Country of publishing house
AU - AUSTRALIA
Number of pages
6
Pages from-to
84-89
UT code for WoS article
000374633900005
EID of the result in the Scopus database
2-s2.0-84978712476