Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F16%3A10327780" target="_blank" >RIV/00216208:11160/16:10327780 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201500761/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201500761/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mnfr.201500761" target="_blank" >10.1002/mnfr.201500761</a>

Result language
angličtina
Original language name
Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats
Original language description
Oral administration of flavonoids is suggested to have an effects on arterial blood pressure. However, the biovailability of nonmetabolized flavonoids is low, thus this study was aimed at testing of effects of quercetin metabolites on vascular smooth muscle cells in vitro and blood pressure in vivo. Several metabolites relaxed isolated rat aorta. The most active of them, 3-(-3-hydroxyphenyl)propionic acid was also tested in vivo on rats and these experiments confirmed in vitro results.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centre of drug-dietary supplements interactions and nutrigenetics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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