Two flavonoid metabolites, 3,4-dihydroxyphenylacetic acid and 4-methylcatechol, relax arteries ex vivo and decrease blood pressure in vivo

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10389884" target="_blank" >RIV/00216208:11160/18:10389884 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1537189118301241" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1537189118301241</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.vph.2018.08.008" target="_blank" >10.1016/j.vph.2018.08.008</a>

Result language
angličtina
Original language name
Two flavonoid metabolites, 3,4-dihydroxyphenylacetic acid and 4-methylcatechol, relax arteries ex vivo and decrease blood pressure in vivo
Original language description
This study aimed at testing the activity of two flavonoid microbial metabolites (4-methylcatechol and 3,4-dihydroxyphenylacetic acid), which can mediate the vasorelaxant effect of orally administered flavonoids. Both metabolites caused a decrease in arterial blood pressure in vivo in rats, their mechanism of action ex vivo was tested.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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