Allergy-Like Immediate Reactions with Herbal Medicines: A Retrospective Study Using Data from VigiBase(R)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F16%3A10328296" target="_blank" >RIV/00216208:11160/16:10328296 - isvavai.cz</a>

Result on the web

<a href="http://link.springer.com/article/10.1007/s40264-016-0401-5" target="_blank" >http://link.springer.com/article/10.1007/s40264-016-0401-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s40264-016-0401-5" target="_blank" >10.1007/s40264-016-0401-5</a>

Result language

angličtina

Original language name

Allergy-Like Immediate Reactions with Herbal Medicines: A Retrospective Study Using Data from VigiBase(R)

Original language description

Introduction Herbal medicines are used worldwide and with an increasing popularity in Western countries. Although often perceived as 'naturally safe', herbals may cause severe adverse drug reactions (ADRs), with immediate allergic reactions being particularly life threatening. Objectives The aim of this study was to analyse immediate allergy-like ADRs to herbals documented in VigiBase(R), the WHO international pharmacovigilance database. Methods The documentation of all suspected ADRs in association with herbal exposure reported to VigiBase(R) from 1969 to August 2014 was retrieved. Among all reports in which WHO-ART reaction terms were indicative of acute allergic reactions, those classified as 'suspect' with a documented causality assessment and latency time of <= 1 day were selected. For the most frequent specific herbal-ADR combinations, the information component (IC) as a measure of disproportionality based on Bayesian statistics was calculated. Results We identified 757 reports out of 1039 ADRs. Products with mixed herbals (36.0 %) as well as those administered orally (63.2 %) were predominant. The most frequent reactions were urticaria and rash (49.2 %). Anaphylactic reactions accounted for 9.5 %. Disproportionally frequent reporting of mouth edema (IC = 1.81) and anaphylactic reactions (IC = 1.24) to Phleum pretense were noted. Conclusion Our findings indicate that herbal medicines for oral use carry a risk of causing immediate allergy-like ADRs. Studies using the Vigibase(R) database can identify specific combinations of particular herbs and adverse reactions. Healthcare professionals and patients should be aware of these risks and report any serious adverse experiences.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FQ - Public health system, social medicine

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Drug Safety

ISSN

0114-5916

e-ISSN

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Volume of the periodical

39

Issue of the periodical within the volume

5

Country of publishing house

NZ - NEW ZEALAND

Number of pages

10

Pages from-to

455-464

UT code for WoS article

000374330200009

EID of the result in the Scopus database

2-s2.0-84959473155