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Allergy-like immediate reactions with herbal medicines in children: A retrospective study using data from VigiBase(R)

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F17%3A10364930" target="_blank" >RIV/00216208:11160/17:10364930 - isvavai.cz</a>

  • Result on the web

    <a href="http://onlinelibrary.wiley.com/doi/10.1111/pai.12778" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/pai.12778</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/pai.12778" target="_blank" >10.1111/pai.12778</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Allergy-like immediate reactions with herbal medicines in children: A retrospective study using data from VigiBase(R)

  • Original language description

    Background: The use of herbal medicines in children and the general population is continually on the rise with an overall herbal lifetime and current use ranging between 0.8%-85.5% and 2.2%-8.9%, respectively. Although acute hypersensitivity reactions are generally considered to be rare, little knowledge exists on the frequency and type of these reactions especially in specific populations like children. Objectives: To assess the patterns of acute hypersensitivity reactions to herbal medicines reported to the WHO global individual case safety report (ICSR) database VigiBase(R) in children. Study design: From the original VigiBase(R) extract for the time between 1968 and 2014, we included all reports with adverse drug reactions (ADR) associated with herbal medicines in children where WHO-ART reaction terms were indicative of acute hypersensitivity reactions. Results: VigiBase(R) contained 2646 ICSRs with 14 860 distinct adverse reactions reported in association with herbal medicine in children. Among those, 79 cases with 107 allergy-like reactions met our inclusion criteria. The most commonly reported WHO-ART terms were urticaria or rash/rash erythematous (59.8%), and allergic reaction (8.4%). The most frequently reported suspected herbal medicines were mixed herbal products (51.4%), Hedera helix (15.0%), and Echinacea purpurea (5.6%). Most frequent routes of administration were oral (75.9%), topical (8.9%), and rectal (3.8%). Over 30% of cases were reported in the age group from 7 to 12 years. The majority of reports were received from Germany (29.1%), Thailand (21.5%), and Australia (11.4%). Conclusion: VigiBase(R) contains a considerable number of acute hypersensitivity reactions in children associated with herbal medicines, including life-threatening reactions such as anaphylactic shock.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Pediatric Allergy and Immunology

  • ISSN

    0905-6157

  • e-ISSN

  • Volume of the periodical

    28

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    DK - DENMARK

  • Number of pages

    7

  • Pages from-to

    668-674

  • UT code for WoS article

    000418437400008

  • EID of the result in the Scopus database

    2-s2.0-85033479712