Statin therapy and plasma cortisol concentrations: A systematic review and meta-analysis of randomized placebo-controlled trials
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F16%3A10328587" target="_blank" >RIV/00216208:11160/16:10328587 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S104366181500256X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S104366181500256X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.phrs.2015.10.013" target="_blank" >10.1016/j.phrs.2015.10.013</a>
Alternative languages
Result language
angličtina
Original language name
Statin therapy and plasma cortisol concentrations: A systematic review and meta-analysis of randomized placebo-controlled trials
Original language description
This study aimed to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) in order to calculate the effect size of statin therapy in changing plasma cortisol concentrations. Following a systematic search in Medline, SCOPUS, Web of Science and Google Scholar databases (by up to March 01, 2015), 7 eligible RCTs were selected. Random-effects meta-analysis suggested a significant increase in plasma cortisol concentrations following statin therapy (WMD: 6.34%, 95% CI: 1.80, 10.87, p = 0.006). Subgroup analysis confirmed the significance of the effect with lipophilic statins comprising atorvastatin, simvastatin, and lovastatin (WMD: 7.00%, 95% CI: 2.21, 11.79, p = 0.004) but not with hydrophilic statins (rosuvastatin and pravastatin) (WMD: 0.60%, 95% CI: 13.46, 14.66, p = 0.933). In the meta-regression analysis, changes in plasma cortisol concentrations following statin therapy were found to be independent of treatment duration. Results of this meta-analysis of RCTs suggest a significant elevation in plasma cortisol levels following statin therapy.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmacological Research
ISSN
1043-6618
e-ISSN
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Volume of the periodical
103
Issue of the periodical within the volume
January
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
17-25
UT code for WoS article
000370457100003
EID of the result in the Scopus database
2-s2.0-84947808489