Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F17%3A10365236" target="_blank" >RIV/00216208:11160/17:10365236 - isvavai.cz</a>

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S1043661816307848" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1043661816307848</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.phrs.2016.11.018" target="_blank" >10.1016/j.phrs.2016.11.018</a>

Result language

angličtina

Original language name

Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials

Original language description

Punica granatum L. (Pomegranate) has been claimed to provide several health benefits. Pomegranate juice is a polyphenol-rich fruit juice with high antioxidant capacity. Several studies suggested that pomegranate juice can exert antiatherogenic, antioxidant, antihypertensive, and anti-inflammatory effects. Nevertheless, the potential cardioprotective benefits of pomegranate juice deserve further clinical investigation. To systematically review and meta-analyze available evidence from randomized placebo controlled trials (RCTs) investigating the effects of pomegranate juice consumption and blood pressure (BP). A comprehensive literature search in Medline and Scopus was carried out to identify eligible RCTs. A meta-analysis of eligible studies was performed using a random-effects model. Quality assessment, sensitivity analysisand publication bias evaluations were conducted using standard methods. Quantitative data synthesis from 8 RCTs showed significant reductions in both systolic [weighed mean difference (WMD): -4.96 mmHg, 95% CI: -7.67 to -2.25, p&lt;0.001) and diastolic BP (WMD: -2.01 mmHg, 95% CI: -3.71 to -0.31, p = 0.021) after pomegranate juice consumption. Effects on SBP remained stable to sensitivity analyses. Pomegranate juice reduced SBP regardless of the duration (&gt;12 wks: WMD = -4.36 mmHg, 95% CI: -7.89 to -0.82, p = 0.016) and &lt;12 wks: WMD= 5.83 mmHg, 95% CI: -10.05 to -1.61, p = 0.007) and dose consumed (&gt;240 cc: WMD= -3.62 mmHg, 95% CI: -6.62 to -0.63, p= 0.018) and &lt;240 cc: WMD= -11.01 mmHg, 95% CI: -17.38 to -4.65, p = 0.001, pomegranate juice per day) whereas doses &gt;240 cc provided a borderline significant effect in reducing DBP. The present meta-analysis suggests consistent benefits of pomegranate juice consumption on BP. This evidence suggests it may be prudent to include this fruit juice in a heart-healthy diet.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmacological Research

ISSN

1043-6618

e-ISSN

—

Volume of the periodical

115

Issue of the periodical within the volume

January

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

149-161

UT code for WoS article

000392790400013

EID of the result in the Scopus database

2-s2.0-84999188049