A UHPLC-UV-QTOF study on the stability of carfilzomib, a novel proteasome inhibitor

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F16%3A10328761" target="_blank" >RIV/00216208:11160/16:10328761 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0731708516301340" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0731708516301340</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jpba.2016.03.015" target="_blank" >10.1016/j.jpba.2016.03.015</a>

Result language
angličtina
Original language name
A UHPLC-UV-QTOF study on the stability of carfilzomib, a novel proteasome inhibitor
Original language description
A new stability-indicating UHPLC-UV method for analysis of carfilzomib, a proteasome inhibitor drug, was developed and validated. The method was utilized to evaluate the effects of forced degradation and to investigate the degradation kinetics, as well asto examine drug stability in a pharmaceutical formulation. In addition a UHPLC-QTOF method was used to identify the main degradation products.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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