Monosodium glutamate-induced obesity changed the expression and activity of glutathione S-transferases in mouse heart and kidney
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F17%3A10364326" target="_blank" >RIV/00216208:11160/17:10364326 - isvavai.cz</a>
Result on the web
<a href="http://www.ingentaconnect.com/content/govi/pharmaz/2017/00000072/00000005/art00003" target="_blank" >http://www.ingentaconnect.com/content/govi/pharmaz/2017/00000072/00000005/art00003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1691/ph.2017.6886" target="_blank" >10.1691/ph.2017.6886</a>
Alternative languages
Result language
angličtina
Original language name
Monosodium glutamate-induced obesity changed the expression and activity of glutathione S-transferases in mouse heart and kidney
Original language description
Obesity may affect activity and/or expression of enzymes participating in xenobiotics' detoxification and antioxidant defense. This study sought to investigate the activities and expression of cardiac and renal glutathione S-transferase (GST) isoforms in order to reveal possible differences between obese and control mice. For this purpose, mice with monosodium glutamate (MSG)-induced obesity were used as an experimental model. Obesity was induced in newborn male mice by repeated s.c. administration of MSG. At 8 months of age, mice were sacrificed and specific activity, protein and mRNA expressions levels of GSTs were analyzed in their heart and kidney. In hearts of obese mice, specific activity of GST was decreased by 51% compared to control. This reduction was accompanied by a decline in GSTP-class protein and Gstp1/2 mRNA expression levels. In contrast, specific activity of GST was elevated by 31% in kidney of obese mice and this increase was accompanied by upregulation of GSTA-class protein and Gsta1/2 mRNA expressions. Increased capacity of renal GSTs together with GSTA upregulation may serve as compensatory mechanism against elevated oxidative stress, which accompanies obesity. On the other hand, decreased cardiac GST activity in obese mice and GSTP downregulation may worsen the defense against oxidative stress and harmful xenobiotics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centre of drug-dietary supplements interactions and nutrigenetics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Die Pharmazie
ISSN
0031-7144
e-ISSN
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Volume of the periodical
72
Issue of the periodical within the volume
5
Country of publishing house
DE - GERMANY
Number of pages
3
Pages from-to
257-259
UT code for WoS article
000400953900003
EID of the result in the Scopus database
2-s2.0-85018334493