Metabolomic profiling of urinary changes in mice with monosodium glutamate-induced obesity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00459565" target="_blank" >RIV/61388971:_____/16:00459565 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/16:00459565 RIV/00216208:11110/16:10314868 RIV/68407700:21230/16:00234547 RIV/00023761:_____/16:N0000018 RIV/00064165:_____/16:10314868

Result on the web

<a href="http://dx.doi.org/10.1007/s00216-015-9133-0" target="_blank" >http://dx.doi.org/10.1007/s00216-015-9133-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00216-015-9133-0" target="_blank" >10.1007/s00216-015-9133-0</a>

Result language

angličtina

Original language name

Metabolomic profiling of urinary changes in mice with monosodium glutamate-induced obesity

Original language description

Obesity with related complications represents a widespread health problem. The etiopathogenesis of obesity is often studied using numerous rodent models. The mouse model of monosodium glutamate (MSG)-induced obesity was exploited as a model of obesity combined with insulin resistance. The aim of this work was to characterize the metabolic status of MSG mice by NMR-based metabolomics in combination with relevant biochemical and hormonal parameters. NMR analysis of urine at 2, 6, and 9 months revealed altered metabolism of nicotinamide and polyamines, attenuated excretion of major urinary proteins, increased levels of phenylacetylglycine and allantoin, and decreased concentrations of methylamine in urine of MSG-treated mice. Altered levels of creatine, citrate, succinate, and acetate were observed at 2 months of age and approached the values of control mice with aging. The development of obesity and insulin resistance in 6-month-old MSG mice was also accompanied by decreased mRNA expressions of adiponectin, lipogenetic and lipolytic enzymes and peroxisome proliferator-activated receptor-gamma in fat while mRNA expressions of lipogenetic enzymes in the liver were enhanced. At the age of 9 months, biochemical parameters of MSG mice were normalized to the values of the controls. This fact pointed to a limited predictive value of biochemical data up to age of 6 months as NMR metabolomics confirmed altered urine metabolic composition even at 9 months

Czech name

—

Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Analytical and Bioanalytical Chemistry

ISSN

1618-2642

e-ISSN

—

Volume of the periodical

408

Issue of the periodical within the volume

2

Country of publishing house

DE - GERMANY

Number of pages

12

Pages from-to

567-578

UT code for WoS article

000368016400022

EID of the result in the Scopus database

2-s2.0-84954377390