Mandelic acid derived ionic liquids: synthesis, toxicity and biodegradability

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F17%3A10364662" target="_blank" >RIV/00216208:11160/17:10364662 - isvavai.cz</a>
Result on the web
<a href="http://pubs.rsc.org/en/content/articlehtml/2017/ra/c6ra25562k" target="_blank" >http://pubs.rsc.org/en/content/articlehtml/2017/ra/c6ra25562k</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c6ra25562k" target="_blank" >10.1039/c6ra25562k</a>

Result language
angličtina
Original language name
Mandelic acid derived ionic liquids: synthesis, toxicity and biodegradability
Original language description
A series of ten ionic liquids (ILs) was synthesised from the renewable resource mandelic acid. The ILs showed low antimicrobial activity towards the thirteen bacterial and twelve fungal strains they were screened against. A general trend of increasing bacterial toxicity in the order methyl ester < ethyl ester < n-butyl ester/amide was observed. IL biodegradability was evaluated using the Closed Bottle test (OECD 301D). Biodegradation increased in the order of increasing alkyl chain length for the ester ILs (methyl < ethyl < n-butyl). Despite none of the ILs presenting as readily biodegradable (> 60% in 28 days), a series of biodegradation transformation products has been proposed based on the degradation of the ester/amide alkyl chain. This data has allowed for an assessment of the effect of IL structural features on toxicity and biodegradation, particularly allowing for a comparison to earlier work where additional oxygen atoms were present to facilitate biodegradation and attenuate toxicity. The mandelic acid derived ILs did not pass the Closed Bottle test (OECD 301D) and can be included in the rules of thumb for the design of biodegradable ILs.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/GA15-07332S" target="_blank" >GA15-07332S: Natural Lactones and Lactams: Towards Diverse Biological Activities through Purposeful Synthetic Manipulations</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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