Esters and amides of hexanoic acids substituted with tertiary amino group in terminal position and their activity as transdermal permeation enhancers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F10%3A00002650" target="_blank" >RIV/62157124:16370/10:00002650 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Esters and amides of hexanoic acids substituted with tertiary amino group in terminal position and their activity as transdermal permeation enhancers

Original language description

Series of alkyl esters of 6-diethylamino-, 6-(pyrrolidin-1-yl)-, 6-(piperidin-1-yl) and 6-(morpholin-4-yl)hexanoic acids and alkylamides of 6-dimethylamino-, 6-(piperidin-1-yl) and 6-(morpholin-4-yl)hexanoic acids, containing 8 ? 12 carbon atoms in alkylchain, were prepared by methods of classical organic synthesis. The appropriate secondary amine was alkylated with ethyl-6-bromohexanoate to give ester of -substituted hexanoic acid, except of ethyl-6-dimethylaminohexanoate (1), which was prepared by Eschweiler-Clarke methylation of 6-aminohexanoic acid followed by direct esterification with ethanol. Resulted esters of -substituted hexanoic acids underwent direct transesterification with long chain alkanols to yield desired amino esters, or they were treated with long-chain alkylamines to prepare secondary amides of the appropriate heterocyclic hexanoic acids. These products were tested on their activity as transdermal permeation enhancers in vitro on the strips of the excised human sk

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Serbian Chemical Society

ISSN

0352-5139

e-ISSN

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Volume of the periodical

75

Issue of the periodical within the volume

5

Country of publishing house

CS - SERBIA AND MONTENEGRO

Number of pages

9

Pages from-to

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UT code for WoS article

000278640900001

EID of the result in the Scopus database

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