Biotransformation of flubendazole and fenbendazole and their effects in the ribwort plantain (Plantago lanceolata)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10364235" target="_blank" >RIV/00216208:11160/18:10364235 - isvavai.cz</a>

Alternative codes found

RIV/61389030:_____/18:00488847

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0147651317305961" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0147651317305961</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ecoenv.2017.09.020" target="_blank" >10.1016/j.ecoenv.2017.09.020</a>

Result language

angličtina

Original language name

Biotransformation of flubendazole and fenbendazole and their effects in the ribwort plantain (Plantago lanceolata)

Original language description

Although veterinary anthelmintics represent an important source of environmental pollution, the fate of anthelmintics and their effects in plants has not yet been studied sufficiently. The aim of our work was to identify metabolic pathways of the two benzimidazole anthelmintics fenbendazole (FBZ) and flubendazole (FLU) in the ribwort plantain (Plantago lanceolata L.). Plants cultivated as in vitro regenerants were used for this purpose. The effects of anthelmintics and their biotransformation products on plant oxidative stress parameters were also studied. The obtained results showed that the enzymatic system of the ribwort plantain was able to uptake FLU and FBZ, translocate them in leaves and transform them into several metabolites, particularly glycosides. Overall, 12 FLU and 22 FBZ metabolites were identified in the root, leaf base and leaf top of the plant. Concerning the effects of FLU and FBZ, both anthelmintics in the ribwort plantain cells caused significant increase of proline concentration (up to twice), a well-known stress marker, and significant decrease of superoxide dismutase activity (by 50%). In addition, the activities of four other antioxidant enzymes were significantly changed after either FLU or FBZ exposition. This could indicate a certain risk of oxidative damage in plants influenced by anthelmintics, particularly when they are under other stress conditions.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/GA15-05325S" target="_blank" >GA15-05325S: Anthelmintics in plants – uptake, biotransformation and transcriptional response</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Ecotoxicology and Environmental Safety

ISSN

0147-6513

e-ISSN

—

Volume of the periodical

147

Issue of the periodical within the volume

January

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

681-687

UT code for WoS article

000416199700085

EID of the result in the Scopus database

2-s2.0-85029513078