Pharmaceuticals in environment: the effect of ivermectin on ribwort plantain (Plantago lanceolata L.)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F20%3A00532397" target="_blank" >RIV/61389030:_____/20:00532397 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/20:10417288

Result on the web

<a href="http://doi.org/10.1007/s11356-020-09442-4" target="_blank" >http://doi.org/10.1007/s11356-020-09442-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11356-020-09442-4" target="_blank" >10.1007/s11356-020-09442-4</a>

Result language

angličtina

Original language name

Pharmaceuticals in environment: the effect of ivermectin on ribwort plantain (Plantago lanceolata L.)

Original language description

The anthelmintic drug ivermectin (IVM), used frequently especially in veterinary medicine, enters the environment mainly via excrements in pastures and could negatively affect non-target organisms including plants. The present study was designed to follow up on our previous investigations into IVM metabolism and its effects in the common meadow plant ribwort plantain (Plantago lanceolata L.) during long-term exposure of both cell suspensions and whole plant regenerants. IVM uptake, distribution, and biotransformation pathways were studied using UHPLC-MS analysis. In addition, the IVM effect on antioxidant enzymes activities, proline concentration, the content of all polyphenols, and the level of the main bioactive secondary metabolites was also tested with the goal of learning more about IVM-induced stress in the plant organism. Our results showed that the ribwort plantain was able to uptake IVM and transform it via demethylation and hydroxylation. Seven and six metabolites respectively were detected in cell suspensions and in the roots of regenerants. However, only the parent drug IVM was detected in the leaves of the regenerants. IVM accumulated in the roots and leaves of plants might negatively affect ecosystems due to its toxicity to herbivorous invertebrates. As IVM exposition increased the activity of catalase, the concentration of proline and polyphenols, as well as decreased the activity of ascorbate peroxidase and the concentration of the bioactive compounds acteoside and aucubin, long-term exposition of the ribwort plantain to IVM caused abiotic stress and might decrease the medicinal value of this herb.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Science and Pollution Research

ISSN

0944-1344

e-ISSN

—

Volume of the periodical

27

Issue of the periodical within the volume

25

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

31202-31210

UT code for WoS article

000537036100006

EID of the result in the Scopus database

2-s2.0-85085874420