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Serum concentrations of TFF3, S100-A11 and AIF-1 in association with systemic inflammatory response, disease stage and nodal involvement in endometrial cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10381053" target="_blank" >RIV/00216208:11160/18:10381053 - isvavai.cz</a>

  • Alternative codes found

    RIV/00179906:_____/18:10381053 RIV/61989592:15110/18:73590205 RIV/61989592:15310/18:73590205

  • Result on the web

    <a href="http://www.degruyter.com/view/j/pteridines.2018.29.issue-1/pteridines-2018-0003/pteridines-2018-0003.xml" target="_blank" >http://www.degruyter.com/view/j/pteridines.2018.29.issue-1/pteridines-2018-0003/pteridines-2018-0003.xml</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1515/pteridines-2018-0003" target="_blank" >10.1515/pteridines-2018-0003</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Serum concentrations of TFF3, S100-A11 and AIF-1 in association with systemic inflammatory response, disease stage and nodal involvement in endometrial cancer

  • Original language description

    To compare preoperative intestinal trefoil factor 3 (TFF3), allograft inflammatory factor-1 (AIF-1) and calgizzarin (S100-A11) serum levels in patients with endometrial cancer, endometrial hyperplasia and in healthy female controls. Serum levels of TFF3, S100-A11 and AIP-1 were analyzed in 98 consecutive patients with histologically verified endometrial cancer, in 43 patients with endometrial hyperplasia diagnosed during hysteroscopy and 24 controls with benign disease. Results were correlated with urinary neopterin/creatinine ratio, serum kynurenine, tryptophan, retinol, alpha-tocopherol, vitamin D, citrulline, C-reactive protein, interleukin-6 and clinical characteristics. S100-A11, and AIF-1 levels were higher in endometrial hyperplasia patients than in controls, and also significantly higher in endometrial cancer than in patients with endometrial hyperplasia. Serum concentrations of TFF3 and S100-A11 were associated with tumor stage and lymph node status. TFF3 exhibited positive correlation with age, IL-6, vitamin D, kynurenine, urinary neopterin/creatinine ratio and kynurenine/tryptophan ratio. S100-A11, as well as AIF-1 correlated positively with Il-6 and TFF3. TFF3, S100-A11 and AIF-1 represent potential biomarkers in patients with endometrial cancer. TFF3 and S100-A11 increase with tumor stage and lymph node involvement, reflecting higher tumor mass that is also associated with increased concentration of biomarkers of immune dysfunction.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/NT13566" target="_blank" >NT13566: Tissue trauma and postoperative stress in patients with surgically treated early endometrial cancer stages</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Pteridines

  • ISSN

    0933-4807

  • e-ISSN

  • Volume of the periodical

    29

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    7

  • Pages from-to

    6-12

  • UT code for WoS article

    000428142600002

  • EID of the result in the Scopus database

    2-s2.0-85043771556