Aqueous injection of quercetin: An approach for confirmation of its direct in vivo cardiovascular effects

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10381904" target="_blank" >RIV/00216208:11160/18:10381904 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0378517318301170" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0378517318301170</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2018.02.036" target="_blank" >10.1016/j.ijpharm.2018.02.036</a>

Result language
angličtina
Original language name
Aqueous injection of quercetin: An approach for confirmation of its direct in vivo cardiovascular effects
Original language description
Quercetin solubility in water is very low and this does not enable direct in vivo (animal) testing. Hence, a solid dispersion of quercetin with polyvinylpyrrolidone (PVP) was developed to prepare an injectable formulation of water-soluble quercetin. The optimized formulation provided a 20,000-fold increase in quercetin solubility. This formulation was tested on conventional and spontaneously hypertensive rats; it lowered their blood pressure in both short-and long-term basis. Pharmacokinetic data are also provided.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30104 - Pharmacology and pharmacy

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)