APPLICATION OF HANSEN SOLUBILITY PARAMETERS IN THE PHARMACEUTICAL INDUSTRY
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43922561" target="_blank" >RIV/60461373:22310/21:43922561 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/21:43922561
Result on the web
<a href="https://www.icct.cz/en/Amca-ICCT/media/content/2021/proceedings/ICCT2021-Proceedings.pdf" target="_blank" >https://www.icct.cz/en/Amca-ICCT/media/content/2021/proceedings/ICCT2021-Proceedings.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
APPLICATION OF HANSEN SOLUBILITY PARAMETERS IN THE PHARMACEUTICAL INDUSTRY
Original language description
The solubility of APIs in water is very crucial for the pharmaceutical industry. Poor water solubility leads to poor bioavailability. The bioavailability of API must be enhanced by a suitable drug formulation, for instance, the amorphous solid dispersions or amorphous solid solutions, to provide safe, quality and effective drugs to patients. In the preformulation process, the proper excipients for formulation with API must be selected. A suitable formulation could prevent, for example, API recrystallization or the inappropriate interactions between API and some excipients. The Hansen solubility parameters can be used to simplify the problem by choosing a proper excipient for the API. This work aimed to verify predictions of compatibility based on the Hansen theory between selected API and chosen polymers to enhance the APIs' bioavailability. The goal was to formulate API with compatible polymers into amorphous solid solutions or amorphous solid dispersions.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Proceedings of the 8th International Conference on Chemical Technology
ISBN
978-80-88307-08-2
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
205-210
Publisher name
Czech Society of Industrial Chemistry
Place of publication
Prague
Event location
Praha
Event date
May 3, 2021
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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