Improving dissolution rate of poorly soluble drugs by milling and co-milling technique

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43922745" target="_blank" >RIV/60461373:22310/21:43922745 - isvavai.cz</a>
Result on the web
<a href="https://www.icct.cz/cs/Amca-ICCT/media/content/2021/proceedings/ICCT2021-Proceedings.pdf" target="_blank" >https://www.icct.cz/cs/Amca-ICCT/media/content/2021/proceedings/ICCT2021-Proceedings.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Improving dissolution rate of poorly soluble drugs by milling and co-milling technique
Original language description
Milling of APIs alone or co-milling of APIs with an excipient are used as one of the efficient techniques that improve physicochemical properties such as solubility and dissolution rate. The enhancement of solubility may be caused by the drug amorphization. Each drug has a different ability to form an amorphous phase (glass forming ability). The influence of excipients is also crucial because the proper choice thereof increases the dissolution rates of API. The aim of this work was to compare the dissolution behavior of drugs having different glass forming ability. Furthermore, the effect of the mixture preparation method was compared in terms of dissolution properties. Our results indicate that co-milling is a valuable approach in enhancing the dissolution rates of poorly water-soluble APIs. Co-milling results in a much faster release of the API, than its milling itself and subsequent mixing with the excipient.
Czech name
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Czech description
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Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the 8th International Conference on Chemical Technology
ISBN
978-80-88307-08-2
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
220-224
Publisher name
Czech Society of Industrial Chemistry
Place of publication
Prague
Event location
Praha
Event date
May 3, 2021
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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