Study of the glass transition of co-amorphous drug by DMA

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F16%3APU120778" target="_blank" >RIV/00216305:26310/16:PU120778 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Study of the glass transition of co-amorphous drug by DMA
Original language description
Nowadays in pharmaceutical research is problem that new chemical entities are poorly water soluble and therefore present a low dissolution rate. One approach to increase their solubility is to convert the crystalline form of a drug into the amorphous form. In this study, the co-amorphous IND-TRY mixtures were prepared by mechanical activation – ball milling. It was given different amount of polyvinylpyrrolidon to the mixture and was characterized. Solid - state properties were analyzed by dynamic mechanical analysis (DMA). It was found that addition of polyvinylpyrrolidon improved stability compared to the pure co-amorphous form. Glass transition state is growing with addition of PVP.
Czech name
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Czech description
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Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
XVI. Workshop of physical chemists and electrochemists Book of abstracts
ISBN
978-80-210-8267-0
ISSN
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e-ISSN
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Number of pages
3
Pages from-to
212-214
Publisher name
MUNI press
Place of publication
Masaryk University, Brno, Czech Republic
Event location
Brno
Event date
Jun 6, 2016
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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