The influence of stevia on the flow, shear and compression behavior of sorbitol, a pharmaceutical excipient for direct compression

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10382146" target="_blank" >RIV/00216208:11160/18:10382146 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26310/17:PU127474
Result on the web
<a href="http://www.tandfonline.com/doi/full/10.1080/10837450.2017.1315132" target="_blank" >http://www.tandfonline.com/doi/full/10.1080/10837450.2017.1315132</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/10837450.2017.1315132" target="_blank" >10.1080/10837450.2017.1315132</a>

Result language
angličtina
Original language name
The influence of stevia on the flow, shear and compression behavior of sorbitol, a pharmaceutical excipient for direct compression
Original language description
Good flow and compaction properties are necessary for the manipulation of particulate material in the pharmaceutical industry. The influence of the addition of an alternative sweetener, rebaudioside A, in a concentration 0.2% w/w and 0.5% w/w on the flow, shear and compaction properties of sorbitol for direct compaction, Merisorb((R)) 200, was investigated in this work. Rebaudioside A worsened the flow properties of sorbitol: the Hausner ratio, the compressibility index and the mass flow rate through the aperture of a model hopper. Using a Jenike shear cell revealed a significant increase in cohesion leading to the decrease of the flow function; moreover, the addition of rebaudioside A increased the total energy for compression of tablets and plasticity estimated by the force-displacement method. Finally, the tablets showed a higher tensile strength and needed longer time to disintegrate compared to the tablets made of sorbitol itself. In view of the results for the free-flowable excipient, sorbitol, the effects of stevia even for a 0.2% w/w concentration have to be carefully considered, particularly whenever used in pharmaceutical formulations of poor flow properties.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
<a href="/en/project/GA16-09161S" target="_blank" >GA16-09161S: Synthesis of multifunctional plasma polymers for polymer composites without interfaces</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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