A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F16%3A10327961" target="_blank" >RIV/00216208:11160/16:10327961 - isvavai.cz</a>
Result on the web
<a href="http://www.degruyter.com/view/j/acph.2016.66.issue-3/acph-2016-0034/acph-2016-0034.xml" target="_blank" >http://www.degruyter.com/view/j/acph.2016.66.issue-3/acph-2016-0034/acph-2016-0034.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/acph-2016-0034" target="_blank" >10.1515/acph-2016-0034</a>
Alternative languages
Result language
angličtina
Original language name
A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride
Original language description
The paper evaluates and compares the compressibility and compactibility of directly compressible tableting materials for the preparation of hydrophilic gel matrix tablets containing tramadol hydrochloride and the coprocessed dry binders Prosolv (R) SMCC 90 and Disintequik (TM) MCC 25. The selected types of hypromellose are Methocel (TM) Premium K4M and Methocel (TM) Premium K100M in 30 and 50 % concentrations, the lubricant being magnesium stearate in a 1 % concentration. Compressibility is evaluated by means of the energy profile of compression process and compactibility by the tensile strength of tablets. The values of total energy of compression and plasticity were higher in the tableting materials containing Prosolv (R) SMCC 90 than in those containing Disintequik (TM) MCC 25. Tramadol slightly decreased the values of total energy of compression and plasticity. Tableting materials containing Prosolv (R) SMCC 90 yielded stronger tablets. Tramadol decreased the strength of tablets from both coprocessed dry binders.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Pharmaceutica
ISSN
1330-0075
e-ISSN
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Volume of the periodical
66
Issue of the periodical within the volume
3
Country of publishing house
CR - COSTA RICA
Number of pages
9
Pages from-to
433-441
UT code for WoS article
000379520700009
EID of the result in the Scopus database
2-s2.0-84978372406