Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F16%3A39902246" target="_blank" >RIV/00216275:25310/16:39902246 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/16:10328902
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejps.2016.08.002" target="_blank" >http://dx.doi.org/10.1016/j.ejps.2016.08.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejps.2016.08.002" target="_blank" >10.1016/j.ejps.2016.08.002</a>

Result language
angličtina
Original language name
Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders
Original language description
The aim of this study is to present the possibility of using of co-processed dry binders for formulation of matrix tablets with drug controlled release. Hydrophilic matrix tablets with tramadol hydrochloride, hypromellose and different co-processed dry binders were prepared by direct compression method. Hypromelloses MethocelTM K4M Premium CR or MethocelTM K100M Premium CR were used as controlled release agents and Prosolv(R) SMCC 90 or DisintequikTM MCC 25 were used as co-processed dry binders. Homogeneity of the tablets was evaluated using scanning electron microscopy and energy dispersive X-ray microanalysis. The release of tramadol hydrochloride from prepared formulations was studied by dissolution test method. The dissolution profiles obtained were evaluated by non-linear regression analysis, release rate constants and other kinetic parameters were determined. It was found that matrix tablets based on Prosolv(R) SMCC 90 and MethocelTM Premium CR cannot control the tramadol release effectively for > 12 h and tablets containing DisintequikTM MCC 25 and MethocelTM Premium CR > 8 h.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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